SWR/J Mice Autoimmune Disease in SWXJ, SJL/J, and Peptides That Mediate Organ-Specific A Novel Class II-Binding Motif Selects
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منابع مشابه
Gene for ovarian granulosa cell tumor susceptibility, Gct, in SWXJ recombinant inbred strains of mice revealed by dehydroepiandrosterone.
Spontaneous, malignant ovarian granulosa cell (GC) tumors occur in pubertal SWR and specific SWXJ recombinant inbred strains of mice. Treatment of these mice with dehydroepiandrosterone (DHEA), an adrenal secretory steroid with anticancer actions against spontaneous and carcinogen-induced tumors of different tissues, gave unexpected results. Diet supplemented with 0.4% DHEA (a) induced signific...
متن کاملSpontaneous malignant granulosa cell tumors in ovaries of young SWR mice.
Granulosa cell tumors (GCT) of the ovary appear spontaneously at 4-6 weeks of age in SWR/J and in SWR/Bm inbred strain mice, with a maximum incidence reached by 10 weeks. Cancer was confirmed by metastasis to abdominal organs and by transplantability of primary tumors to histocompatible hosts. Results of genetic crosses showed that GCT appear in SWR X SJL F1 but not in SJL X SWR F1 nor in other...
متن کاملSpontaneous Malignant Granulosa Cell Tumors in Ovaries of Young SWR Mice1
Granulosa cell tumors (GCT) of the ovary appear sponta neously at 4-6 weeks of age in SWR/J and in SWR/Bm inbred strain mice, with a maximum incidence reached by 10 weeks. Cancer was confirmed by metastasis to abdominal organs and by transplantability of primary tumors to histocompatible hosts. Results of genetic crosses snowed that GCT appear in SWR x SJL F, but not in SJL x SWR F, nor in othe...
متن کامل(SWR x SJL)F1 mice: a new model of lupus-like disease
During the study of autoimmune models we found that (SWR x SJL)F1 mice (both parental strains with the V beta a phenotype) spontaneously produced immunoglobulin G (IgG) antibodies directed against Sm/U1 small nuclear ribonucleoproteins (snRNPs). In some of these females, the presence of these autoantibodies was found as early as 10 wk of age. Their frequency increased with age i.e., 70% at 40 w...
متن کاملGene for Ovarian Granulosa Cell Tumor Susceptibility, Get, in SWXJ Recombinant Inbred Strains of Mice Revealed by Dehydroepiandrosterone1
Spontaneous, malignant ovarian granulosa cell (GC) tumors occur in pubertà !SWR and specific SWXJ recombinant inbred strains of mice. Treatment of these mice with dehydroepiandrosterone (DHEA), an ad renal secretory steroid with anticancer actions against spontaneous and carcinogen-induced tumors of different tissues, gave unexpected results. Diet supplemented with 0.4% DHEA (a) induced signifi...
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تاریخ انتشار 2002